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Valneva launches trials of Covid-19 vaccine in UK

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French-Austrian biotech firm Valneva said Wednesday it will begin clinical trials of its Covid-19 vaccine candidate in Britain, where the government has already ordered at least 60 million doses.

The specialist vaccine developer said the phase 1 and 2 trials, involving around 150 healthy adults, would focus on the drug’s safety and ability to stimulate an immune response at three different doses.

Supported by Britain’s National Institute of Health, the tests will takes place at several sites around the UK.

Valneva hopes to determine the optimal dose of the vaccine in the second quarter of next year, putting it on track for approval by the autumn — several months later than its previous mid-2021 ambition.

As well as a firm order for 60 million doses, Britain has options to buy a further 130 million between 2022 and 2025 in a deal worth up to 1.4 billion euros ($1.7 billion, £1.2 billion).

Valneva’s vaccine contains a deactivated form of the virus that can prompt an immune response from the body but cannot harm health, the same technique used in its existing inoculation against Japanese encephalitis.

Based in Nantes in western France, Valneva employs around 500 people worldwide and already has two vaccines on the market, for Japanese encephalitis and cholera.

It has a further vaccine against Lyme disease in phase 2 trials and a fourth, for the chikungunya virus, in phase 3.

Valneva is already listed on the Paris stock market and aims to secure a New York listing next year.

– AFP

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Netizens: Was Ho Ching smirking before entering Dr Lee Wei Ling’s funeral?

On 10 October at around 8.30 PM, Senior Minister Lee Hsien Loong and his wife, Ho Ching, were spotted arriving at Dr Lee Wei Ling’s funeral. While Singaporeans mourned Dr Lee’s passing, some netizens, after viewing media footage, questioned whether Mdm Ho was smirking before entering the funeral.

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Dr Lee Wei Ling, the daughter of Singapore’s founding Prime Minister, Lee Kuan Yew, passed away on 9 October at the age of 69, at her family home at 38 Oxley Road.

Lee Hsien Yang (LHY), Dr Lee’s brother, announced her passing on social media, and had earlier requested that the wake and funeral remain a private affair.

He also noted that respects could be paid on a strict queue basis, adding, “There will be no exceptions, not even for VIPs,” to ensure that everyone is treated equally during the visitation period.

The wake is being held at the Pearl & Sapphire Hall of Singapore Casket, located at 131 Lavender Street, Singapore. Public visitation is open from 2 PM to 10 PM on 10 October, and from 10 AM to 10 PM on 11 October. The final visitation period is scheduled for 10 AM to 1 PM on 12 October.

Despite the request for privacy, mainstream media (MSM) representatives have gathered outside the Singapore Casket building.

MSM reporters are focused on whether Dr Lee’s elder brother, Senior Minister Lee Hsien Loong, will attend her funeral.

On Thursday (10 October ) at around 8.30pm, MSM spotted Senior Minister Lee and his wife, Ho Ching, entering Singapore Casket.

SM Lee and His Wife Attended the Wake for Approximately 10 Minutes

According to Lianhe Zaobao, SM Lee and his wife stayed at the wake for about 10 minutes and did not provide any comments to the media.

Comments on social media pages of various media outlets show Singaporeans pouring in with condolence messages, remembering Dr Lee’s contributions to Singapore’s medical field.

They praised her as a low-profile and modest woman, despite being a President’s Scholar and the Head of the Neurology Department.

Many noted how much she resembled her mother, who also shunned the limelight, even at their funerals.

However, some netizens, after viewing videos and photos taken by mainstream media, questioned whether Mdm Ho Ching was smirking before entering Dr Lee’s funeral.

Netizens Urge Media and Public to Give Grieving Family Space

Some netizens disagreed with the speculation surrounding Mdm Ho Ching’s expression in the media footage, urging others to refrain from making unfounded assumptions.

They called for compassion, emphasizing the need to give the grieving family some space.

Some netizens also recalled the Lee family feud surrounding the 38 Oxley Road house, where Dr Lee and LHY accused their brother, SM Lee, of opposing their father’s wish to have the house demolished after his passing.

One netizen lamented the strained relationship within the Lee family, questioning why there was supposed to be a sense of family, yet it felt more like guests attending the wake.

Another commented on the fact that SM Lee and his wife attended the wake rather than being involved in arranging it, especially given that Dr Lee was unmarried and their parents are no longer around, “it says alot about their relationship.”

One netizen speculated that Dr Lee might be SM Lee’s greatest regret in life, as he had failed to mend his relationship with her.

The comment added, “Attend or not attend his sister’s wake doesn’t really matter since the person had already gone.”

Meanwhile, some netizens questioned the media’s actions, pointing out that despite LHY’s request for no media coverage, reporters were still camping outside Dr Lee’s funeral.

 

 

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RDU urges AGC clarify charge amendments and sentencing stance in Iswaran case

Red Dot United (RDU) has urged the Attorney-General’s Chambers (AGC) to explain its rationale for amending charges and sentencing recommendations against former Transport Minister S. Iswaran. RDU questioned the abrupt change on 24 September, seeking clarity on why the initial corruption charges under the Prevention of Corruption Act were reduced to lesser offences.

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SINGAPORE: Alternative party Red Dot United (RDU) called on The Attorney-General’s Chambers (AGC) to provide a detailed and public explanation of the rationale behind their amendments to the charges and their sentencing recommendations against former Transport Minister S. Iswaran.

In a statement issued on Thursday (10 October), RDU’s Secretary-General, Ravi Philemon, stressed that this is a matter of significant public interest, compelling the party to raise critical questions about transparency.

He emphasised the need for such clarity to restore public confidence in Singapore’s institutions.

The statement referenced the sentencing of Mr Iswaran to 12 months’ imprisonment for accepting valuable gifts, under Section 165 of the Penal Code.

“We respect the right of Mr Iswaran and his family for privacy as they come to terms with his crime. But it is important to discuss the offences committed and how the case has unfolded over the past 15 months,” said Philemon.

RDU’s call comes on the heels of an earlier statement by the Progress Singapore Party (PSP), which also sought greater clarity from the AGC regarding its prosecutorial decisions in the Iswaran case.

Concerns Over Amended Charges

The AGC’s decision to amend the initial charges against Mr Iswaran has raised significant concerns.

Initially, the former minister faced 35 charges, including two under the Prevention of Corruption Act (PCA), for corruption involving over S$400,000 worth of valuable items.

However, days before the trial was set to commence in September 2024, the AGC reduced these to lesser offences under Section 165, drastically lowering the potential penalties.

RDU has questioned why the AGC initially determined that the PCA charges were justified and why this assessment changed as the trial approached.

Philemon asked, “Was there new information that made the original charges untenable, or did the AGC reassess the risks involved in proceeding with a full trial? ”

“The public deserves clarity, especially given the serious nature of the accusations.”

Lenient Sentencing Recommendations

Another point of contention highlighted by RDU is the AGC’s sentencing recommendation.

Despite the extensive nature of Mr Iswaran’s wrongdoing, the AGC recommended a sentence of just six to seven months.

However, Justice Vincent Hoong handed down a 12-month jail term, almost double what was sought by the prosecution.

Philemon remarked, “As a former minister, Mr Iswaran occupied a position of immense responsibility, and his actions not only betrayed public trust but also set a dangerous precedent for how corruption cases involving high-ranking officials are managed.”

“Given this, we urge the AGC to address if it took such a lenient position and whether such considerations are consistent across similar cases,” he added.

Lack of Transparency in Related Cases

RDU also expressed concerns over the status of other individuals named in connection with the case, such as Mr Ong Beng Seng and Mr Lum Kok Seng.

While Mr Ong has since been charged, RDU questioned why it took so long and what criteria the AGC used when deciding whether to pursue charges against associated parties.

“This piecemeal approach to prosecuting such a high-profile case suggests a lack of consistent standards and undermines public confidence in the impartiality of our legal system.,” said Philemon.

Commendation of Judge’s Decision

Despite concerns over the AGC’s actions, RDU praised Justice Vincent Hoong for imposing a sentence that more appropriately reflected the seriousness of the offences.

“His decision underscores the importance of accountability and reinforces the need for robust sentencing to reflect the gravity of offences committed by individuals holding high public office,” Philemon added.

RDU stressed that transparency is crucial to upholding good governance, asserting that Singaporeans deserve clear answers on matters that may compromise the integrity of the public service.

The party expressed hope that the authorities would address these concerns and build long-term trust and understanding through enhanced openness.

AGC Cited Evidentiary Risks in Reducing Iswaran’s Corruption Charges

In a statement issued on 24 September, the AGC cited substantial evidentiary risks in proving the original corruption charges, which involved  Ong Beng Seng and Lum Kok Seng.

The AGC noted that proving the original corruption charges under PCA would have been difficult due to the involvement of both Iswaran and Ong as primary parties.

Both would have had to implicate themselves to establish corrupt intent.

The AGC explained that “there are two primary parties to the transactions, and both would have an interest in denying corruption in the transactions.” This made securing a conviction for corruption highly uncertain.

In light of these risks, the AGC amended the charges to offenses under Section 165 of the Penal Code, which carries a lower evidentiary threshold and a reduced maximum sentence of two years’ imprisonment.

According to AGC, the amendment was made to ensure a fair and just outcome while considering public interest.

 

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